刘家恩

本文作者：佚名   本文来源：原创   添加日期：2015年8月13日

刘家恩 首席专家 生物学博士 教授

刘家恩博士1977年进入湖北医科大学医疗系（现武汉大学医学部)，1985年获湖北医科大学妇产科硕士学位。1989年赴比利时留学，1995年获比利时布鲁塞尔自由大学生物医学博士学位。1992年-1995年任该大学医学院生殖医学中心卵浆内单精子注射（ICSI）实验室（该实验室是ICSI的创始机构）首席主任和胚胎着床前遗传病诊断（PGD）实验室主任；1995年-2002年任美国大巴尔的摩医学中心人工辅助生殖中心主任和PGD室主任。2003年被聘为武汉大学教授。刘家恩博士长期从事不孕不育症的治疗和试管婴儿工作。在国际著名学术刊物上发表论著76篇，有多项首创技术，例如：世界首例植入前胚胎DMD诊断技术、睾丸精子体外培养成熟技术、世界首例将ICSI应用于PGD、超快速植入前胚胎单细胞DNA荧光原位杂交技术（FISH）、植入前胚胎单细胞重复DNA荧光原位杂交技术等。并数次在国际上本领域获奖：

1990年 比利时—荷兰胚胎学学会授予“青年科学家奖”；

1993年 美国和欧洲生殖医学会共同授予“大西洋生殖医学交流奖”；

1998年 美国和世界生殖与避孕学会共同授予“辅助生殖技术奖”。

刘家恩博士在试管婴儿方面作为第一作者在国际刊物上发表的代表文章有：

Liu, J., Nagy, Z., Joris, H., Tournaye, H., Devroey, P. and Van Steirteghem, A. (1994) Intracytoplasmic sperm injection does not require special treatments of the spermatozoa. Hum. Reprod., 9, 1127-1130.

Liu, J., Nagy, Z., Joris, H., Tournaye, H., Devroey, P. and Van Steirteghem, A. (1995) Successful fertilization and establishment of pregnancies after intracytoplasmic sperm injection in patients with globozoospermia. Hum. Reprod., 10, 626-62.

Liu, J., Nagy, Z., Joris, H.,Tournaye, H., Smitz, J., Camus, M., Devroey, P. and Van Steirteghem, A. (1995) Analysis of 76 total-fertilization-failure cycles out of 2732 intracytoplasmic sperm injection cycles. Hum. Reprod., 10, 2630-2636.

Liu, J., Katz, E., Garcia, J.E., Compton, G. and Baramki, T.A. (1996) Successful in vitro maturation of human oocytes not exposed to hCG during ovulation induction, resulting in an ongoing pregnancy. Fertil. Steril., 67, 566-568.

Liu, J., Garcia, J.E. and Baramki, T.A. (1996) The difference in outcome of in-vitro culture of human testicular spermatozoa between obstructive and non-obstructive azoospermia. Hum. Reprod., 11, 1587-1588.

Liu, J., Tsai, Y.L., Katz, E., Garcia, J.E., Compton, G. and Baramki, T.A. (1997) High fertilization rate obtained after intracytoplasmic sperm injection with 100% non-motile spermatozoa selected by using a simple modified hypo-osmotic swelling test. Fertil. Steril., 68, 373-375.

Liu, J., Tsai, Y.L., Katz, E., Garcia, J.E., Compton, G. and Baramki, T.A. (1997) Outcome of in-vitro culture of fresh and frozen-thawed human testicular spermatozoa. Hum. Reprod.,12, 1667-1672.

Liu, J., Zheng, Y.Z., Baramki, T.A., Compton, G., Yazigi, R.A. and Katz, E. (2000) Cryopreservation of a small number of fresh human testicular spermatozoa and testicular spermatozoa cultured in vitro for three days in an empty zona pellucida. J. of Andrology, 21, 409-413.

Liu, J., Van den Abbeel E. and Van Steirteghem, A.C. (1993) Assessment of ultrarapid and slow freezing procedures for 1-cell and 4-cell mouse embryos. Hum. Reprod., 8, 1115-1119.

Liu, J., Van den Abbeel E. and Van Steirteghem, A.C. (1993) The in-vitro and in-vivo developmental potential of frozen and non-frozen biopsied 8-cell mouse embryos. Hum. Reprod., 8, 1481-1486.

Liu, J., Lissens, W, Devroey P, Van Steirteghem A, Liebaers I. (1992) Efficiency and accuracy of polymerase-chain-reaction assay for cystic fibrosis allele ?F508 in single cell. Lancet, 339:1190-1192.

Liu, J., Lissens, W., Devroey, P., Van Steirteghem, A.C., and Liebaers, I. (1993). Polymerase chain reaction analysis of the cystic fibrosis ? F508 mutation in human blastomeres following oocyte injection of a single sperm from a carrier. Prenatal Diagn., 13,873-880.

Liu, J., Lissens, W., Devroey, P., Van Steirteghem, A.C., and Liebaers, I. (1993). Efficiency of polymerase chain reaction assay for cystic fibrosis in single human blastomeres according to the presence or absence of nuclei. Fertil. Steril., 59,815-819.

Liu, J., Lissens, W., Devroey, P., Van Steirteghem, A.C., and Liebaers, I. (1994) Amplification of X- and Y-chromosome specific regions from single human blastomeres by PCR for sexing of preimplantation embryos. Hum. Reprod., 9,716-720.

Liu, J., Lissens, W., Silber, S.J., Devroey, P., Liebaers, I. and Van Steirteghem, A. (1994) Birth after preimplantation diagnosis of the cystic fibrosis ?F508 mutation by polymerase chain reaction in human embryos resulting from intracytoplasmic sperm injection with epididymal sperm. JAMA , 272, 1858-1860.

Liu, J., Lissens, W., Devroey, P., Liebaers, I. and Van Steirteghem, A. (1995) Normal pregnancy after preimplantation DNA diagnosis of a dystrophy gene deletion. Prenatal Diagn., 15, 351-358.

Liu, J., Lissens, W., Devroey, P., Liebaers, I. and Van Steirteghem, A. (1996) Cystic fibrosis, Duchenne muscular dystrophy and preimplantation genetic diagnosis. Hum. Reprod. Update, 2, 531-539.

Liu, J., Tsai, Y.L., Zheng, Y.Z., Baramki, T.A., Yazigi, R.A. and Katz, E. (1998) The potential of repeated fluorescence in situ hybridization in the same human blastomeres for preimplantation genetic diagnosis. Fertil. Steril., 70,729-733.

Liu, J., Zheng, Y.Z., Baramki, T.A., Yazigi, R.A., Compton, G. and Katz, E. (1998) Ultrarapid detection of sex chromosomes using fluorescence in situ hybridization with direct label DNA probes in single human blastomeres, spermatozoa, amniocytes and lymphocytes. Fertil. Steril., 70. 927-932.

Liu, J., Tsai, Y.L., Zheng, Y.Z., Baramki, T.A., Yazigi, R.A., Compton, G. and Katz, E. (1998) Feasibility study of repeated fluorescent in-situ hybridisation in the same human blastomeres for preimplantation genetic diagnosis. Mol. Hum. Reprod., 4,972-977.

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